2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-120685
    WAY-125971 139047-48-6 98%
    WAY-125971, a propylamine analogue, is a potent and specific blocker of the rectifier potassium current (IK). WAY-125971 can be used for the study of arrhythmia.
    WAY-125971
  • HY-120686
    S-14671 135722-27-9 98%
    S-14671 is a high-affinity 5-HT1A agonist (pKi=9.3). S-14671 can be used for research on neurological diseases, such as anti-anxiety, anti-depression, etc.
    S-14671
  • HY-120688
    L-772405 177947-03-4 98%
    L-772405 is a selective 5-HT1D receptor agonist with the Ki values of 318, 29 and ＞ 1000 nM aganist guinea pig 5-HT1B receptor, guinea pig 5-HT1D receptor and rat 5-HT rransporter, respectively. L-772405 decreases the potassium-induced outflow of 5-HT with an IC50 value of 240 nM.
    L-772405
  • HY-120695
    Nafiverine 5061-22-3 98%
    Nafiverine is an antispasmodic agent. Nafiverine shows a high myolytic activity on the smooth muscles of the ileum, uterus, and coronary vessels.
    Nafiverine
  • HY-120699
    RO5488608 1337920-46-3 98%
    RO5488608 is a negative allosteric metabotropic modulator of glutamate receptor 2/3. RO5488608 inhibits LY354740 (HY-18941)-induced intracellular Ca2+ release and can be used for study of antidepressant.
    RO5488608
  • HY-120710
    DNS-8254 1821107-98-5 98%
    DNS-8254 is an oral active and brain-penetrating PDE2a inhibitor with the IC50 of 8 nM. DNS-8254 shows memory enhancing effects in a rat model.
    DNS-8254
  • HY-120727
    VU0364289 1242443-29-3 99.52%
    VU0364289 is a highly selective mGlu5 positive allosteric modulator (PAM) (binds to the MPEP (HY-14609A) site), with an EC50 of 1.6 µM. VU0364289 can reverse amphetamine-induced hyperlocomotion in a dose-dependent manner, which can be used for schizophrenia and other psychiatric research.
    VU0364289
  • HY-120769
    Pimprinine 13640-26-1
    Pimprinine is a potent monoamine oxidase inhibitor, could be isolated from fermented broths. Pimprinine has antioxidative activity and anticonvulsant activity. Pimprinine inhibits tremorine-induced tremors and analgesia in mice.
    Pimprinine
  • HY-120783
    Lu AF58801 1531592-40-1 98%
    Lu AF58801 is a potent, orally available, brain-penetrant positive allosteric modulator of α7 nicotinic acetylcholine receptors with efficacy in a novel object recognition task in mice. Lu AF58801 was shown to selectively enhance the activity of α7 nicotinic acetylcholine receptors. Lu AF58801 was able to improve cognitive function in mice treated with subchronic fluchlorothiazol (PCP).
    Lu AF58801
  • HY-120796
    MW108 hydrochloride 1454658-89-9 98%
    MW108 (MW01-11-108SRM) hydrochloride is a selective and CNS-penetrant p38αMAPK inhibitor with a Ki of 114 nM. MW108 hydrochloride ameliorates beta-amyloid induced synaptic and cognitive dysfunction.
    MW108 hydrochloride
  • HY-120820
    LY320954 182633-59-6 98%
    LY320954 is a selective 5-HT2A receptor antagonist, with a Ki of 96 nM. LY320954 potently inhibits Ca2+ influx in the functional assay (EC50 of 35.5 nM). LY320954 inhibits 5-HT-induced paw swelling in rats, with ED50 of 4.8 mg/kg.
    LY320954
  • HY-120842
    RLH-033 157097-10-4 98%
    RLH-033 is a potent and selective ligand for the sigma 1 recognition site. RLH-033 has high affinity for sigma 1 sites labeled by [3H](+)-pentazocine with a Ki of 50 pM.
    RLH-033
  • HY-120862
    L 368935 145878-31-5 98%
    L 368935 is a cholecystokinin B receptor (CCKB receptor) antagonist. L 368935 is a brain-penetrant and centrally active compound.
    L 368935
  • HY-120879
    PF2562 1609258-91-4 98%
    PF2562 (Example 6), a dopamine D1 ligand, ascts as a dopamine D1 agonist or partial agonist. PF2562 binds to human D1 receptor with a Ki of 113 nM. PF2562 exhibits activity against human D1 cAMP with an EC50 of 568 nM in HTRF assay.
    PF2562
  • HY-120928
    S 16474 149250-10-2 98%
    S 16474 is a cyclic peptide with antagonistic effects on NK1 and NK2 receptors. S 16474 can be used in the study of neurogenic inflammation.
    S 16474
  • HY-120935
    (R)-Dabelotine 152886-02-7 98%
    (R)-Dabelotine is the R-isomer of Dabelotine and functions as an adrenergic agonist, making it valuable in dementia research.
    (R)-Dabelotine
  • HY-120939
    S14063 137289-83-9 98%
    S14063 is a potent 5-HT1A receptor antagonist. S14063 is devoid of β-adrenoceptor blocking properties.
    S14063
  • HY-120946
    VMY-2-95 1434047-61-6 98%
    VMY-2-95 is an oral active and blood-brain barrier (BBB) penetrant α4β2 nicotinic acetylcholine receptor desensitizer. VMY-2-95 can be used for study of depression or addiction.
    VMY-2-95
  • HY-120970
    Bis(7)-tacrine dihydrochloride 224445-12-9 98%
    Bis(7)-tacrine dihydrochloride is a dimeric AChE inhibitor derived from tacrine. Bis(7)-tacrine dihydrochloride prevents glutamate-induced neuronal apoptosis by blocking NMDA receptors. Bis(7)-tacrine dihydrochloride is a potent GABAAreceptor antagonist. Bis(7)-tacrine dihydrochloride has the potential for the research of Alzheimer's disease .
    Bis(7)-tacrine dihydrochloride
  • HY-120985
    Araguspongin B 123000-02-2 98%
    Xestospongins and araguspongins are marine natural products first isolated from Pacific basin sponges, and noted to have vasodilatory properties.1 Inositol phosphates (IP) are important signal transduction messengers acting via IP3 receptors to promote the mobilization of Ca2+ from intracellular stores.2 Araguspongin B antagonizes the calcium-releasing action of inositol 1,4,5-trisphosphate at the receptor level in cerebral microsomes, with an IC50 of 0.6 μM. It is nearly as potent as xestospongin C as an antagonist of the IP3 receptor.
    Araguspongin B
Cat. No. Product Name / Synonyms Application Reactivity